General Anaesthesia

General anaesthesia and sedation are important techniques which have quickly developed in the last years. Intravenous anaesthesia regimes with target controlled infusions (TCI) are our high-quality standard for adults and children. This research topic concentrates on:

• Patient’s safety during total intravenous anaesthesia (TIVA) performed in our clinic as target controlled infusion (TCI): awareness, haemodynamic stability
• Drug interactions between local anaesthetics and intravenous anaesthetics: pharmacokinetic and pharmacodynamic studies

Central compartment represents blood or plasma
Second compartment could represent the highly perfused tissues
Third compartment could represent the poorly perfused tissues
k₂₁ k₁₂ k₃₁ k₁₃ and k_1e are intercompartmental distribution rate constants, i.e. they describe the proportions of drug exchanged between compartments per unit time
k₁₀ is the elimination rate constant from the central compartment
k_eo is the rate constant describing drug elimination from the effect side

Ongoing Projects:

• Target controlled infusion with Profofol: is there a need for BIS-monitoring?
• The effects of different drugs on local anaesthetic’s pharmacokinetics / pharmacodynamic