Effects of different anaesthetics on endothelial function

Another important collaboration with an internationally highly recognised group in the field of cardiovascular research has been established with Prof. Michael Zaugg, Head of the Cardiovascular Anaesthesia Research Laboratory, Department of Anaesthesiology and Pain Medicine, and Director of Perioperative Translational Medicine at the Mazankowski Alberta Heart Insitute, University of Alberta (Canada). His important inputs offer the basis for our ischemia-reperfusion injury studies:

Effects of different anaesthetics on endothelial function

• The effect of different anaesthetics and analgesics on endothelial ischemia-reperfusion injury protection
• The effect of different local anaesthetic techniques on ischemia-reperfusion injury protection

Ongoing Projects

• The effect of different anaesthetics on endothelial function after ischemia-reperfusion injury in young healthy and elderly at-risk patients following major joint surgery

Two-dimensional (A) and Doppler (B) images of the brachial artery. Representation of the artery diameter is displayed (arrow).

 
Flow mediated dilation schema: in response to different changes in shear stress. * = very short-term changes;** = changes taking place over minutes; *** = changes taking place over many minutes or hours

PGI2 = prostacycline; EDHF = endothelium-derived hyperpolarizing factor; Kc = calcium-activated potassium