Clinical research orthopaedics
The individual teams engaged in clinical research are identifying methods of diagnosis and treatment that are still unsatisfactory today. These problems are then studied systematically and proposed solutions developed in close cooperation with research institutes. The proposed solutions are then examined for feasibility and ethical acceptability.
In the event that very promising new methods – which are safe for the patient – are found and developed, they undergo clinical testing subject to the strictest scientific and ethical criteria. Should they prove successful, they will also be made available to other medical facilities.
Research topics in the orthopaedic teams
Research on the shoulder / elbow
- Rotator cuff tears lead to painful restricted function of the arm and time off work: What causes rotator cuff tears? What preventative measures are needed, and what treatment is effective?
- Secondary changes after rotator cuff tears, especially in the muscles, are progressive and irreversible: the aetiology and molecular mechanisms involved in the fatty infiltration of muscles. Can we reverse these changes?
- Which ruptured tendons need surgical repair? Which ones should be treated differently?
- Shoulder joint prostheses have advanced considerably, with the optimal selection and implantation of the replacement shoulder joint and analysis of the long-term results, also as regards their combination with additional procedures such as tendon grafting.
Research on the spine
One component of highly specialised university spine surgery is a scientific and analytical way of thinking and a procedure based on the existing evidence. Determining new findings depends on an understanding of existing knowledge and ensures that treating surgeons are always up to date.
The scientific goals of spine surgery at the Balgrist University Hospital are:
- answering open clinical questions in direct clinical application. The team is focussing on the predictability of therapeutic success using the latest technology and on innovative surgical techniques based on considerations of patient-specific anatomy/pathology and kinematics.
- patient-specific simulation and risk reduction of surgical procedures. Our unique cooperation with engineers, biomechanics, biologists, IT specialists, and other disciplines (Balgrist Campus) makes all this possible.
Videos about research and science projects (broadcasted in German)
Hightech in the operation theatre
Balgrist Campus image film
Research on the hand
- Potential and feasibility of computer-assisted surgery in trauma: use in fractures from the CARD technology experience gained with osteotomies
- Mechanisms of forearm instability and stiffness: development of a bone/soft tissue model of the forearm
- Standard implants not compatible with anatomical differences: optimisation of standard plates for patient-specific implants
Research on the hip
- Greater trochanteric pain syndrome (GTPS): natural course of hip abductor tendinopathy
- Anatomical reconstruction with total hip joint replacement: 3D planning and navigation in primary total hip joint replacements
Research on the knee
- Instability: patellofemoral joint. When is surgery needed and which operation?
- Cartilage: How can we slow down the development of osteoarthritis?
- Instability: anterior cruciate ligament (ACL) injuries Osteolytic reaction after repairs
- Early osteoarthritis: osteotomies How much correction and effect on gait? Regenerative treatment
- Pain after total knee joint replacement Kinematics and gait analysis, ligament balancing, and coordination
Research on the foot
- Corrective osteotomies: relevance of CARD and extended reality
- Treatment of focal cartilage damage: long-term results with autologous matrix-induced chondrogenesis (AMIC) repairs
- Tendon disorders: treatment of Achilles tendinopathy
Research in technical orthopaedics
- Research on the pathological mechanisms in Charcot’s foot: Is a Charcot protein responsible for disease progression?
- Personalised treatment for poorly healing wounds: What is the ideal material for wound therapy, when to use it, and for whom?
- Development of sensory prostheses: Can specific neurological stimulation relieve phantom pain?
- Definition of tumour size and activity: What are the right tools for predicting tumour activity?
- Intraoperative safety and precision in tumour resection: How can the planning and performance of cancer surgery be improved with technical aids?
- Translational research
Improved systemic treatment of patients with sarcoma: measurement of cancer cells in the blood (‘liquid biopsy’) for early diagnosis and determination of prognosis, as well as for monitoring the response to treatment.
CARD (Computer Assisted Research & Development)
- Functional preoperative planning: necessity of predicting the patient’s postoperative function
- Automation: reducing costs with computer-assisted surgery
- New indications: improved outcomes by using CARD navigation for more surgical procedures