PD Dr. med. Daniel Andreas Müller
Highly specialized treatment for bone and soft-tissue tumors
Balgrist belongs to the Zurich Sarcoma Center
Bone and soft-tissue tumors are extremely complex diseases that present a particular challenge because of their rarity. In the Zurich Sarcoma Center, which is unique in Switzerland, we care for patients thought to have a tumor in the musculoskeletal system – with comprehensive interdisciplinary treatment.
Interdisciplinary treatment for tumor patients.
Balgrist – the only orthopedic hospital for tumor surgery in Zurich
The treatment of malignant bone and soft-tissue tumors is considered to be highly specialized medicine (HSM). For this reason, the necessary surgical procedures may be carried out at only a few hospitals in Switzerland. Balgrist University Hospital is the only orthopedic hospital with service level agreement for the treatment of bone cancers from the Zurich Cantonal Department of Health.
Certified Sarcoma Center
- The University Sarcoma Center in Zurich is the only center of excellence in Switzerland that is certified by the German Cancer Society (DKG) in accordance with international guidelines.
- Interdisciplinary cooperation of Tumor Surgery at Balgrist with Oncology and Radio-oncology at the Zurich University Hospital (USZ) provides highly skilled and comprehensive treatment for the patients concerned. Balgrist also functions as a surgical partner to the Zurich University Children’s Hospital.
- The Zurich Sarcoma Center works closely with many national and international hospitals and universities, enabling our experts to access a worldwide network of specialists and discuss complex treatment strategies.
What are bone and soft-tissue tumors?
As with the internal organs, tumors may develop in bone and soft tissues. They are most commonly found in the arms, legs and pelvis, and are often located near to a joint. Bone and soft-tissue tumors are classified as benign and malignant (cancer). Malignant tumors carry the risk of spreading to other parts of the body and forming new lesions, especially in the small blood vessels in the lungs.
What is a sarcoma?
Sarcoma is the technical term for malignant tumors (cancers) that arise directly in bone or soft tissues (fatty tissue, muscles, connective tissue, and nerve tissue). If cancer spreads to the bones from other organs (prostate, breast, lungs, thyroid gland, etc.), we call these lesions secondaries or metastases.
What sort of tumors are there?
There are many different types of bone and soft-tissue tumor. The three most common cancers in bone are osteosarcomas, chondrosarcomas and Ewing’s sarcomas. Liposarcoma (in fatty tissue) is the most common malignant tumor found in soft tissue. Each type of tumor requires individual treatment.
What causes bone and soft-tissue cancer?
Compared with other types of cancer, bone and soft-tissue cancers are very rare. No clear cause has yet been discovered: lifestyle and diet in particular do not seem to affect their development.
How are they diagnosed?
How are bone and soft-tissue tumors discovered?
In most cases, pain or a palpable lump brings the patient to their general practitioner or an orthopedic surgeon. X-rays or MRI scans are the best way of showing changes in the bones or growths in the tissues. Tumors are often incidental findings, for example seen on an X-ray taken after an accident.
What investigations are necessary?
Whenever a bone or soft-tissue tumor is suspected, our tumor team takes over the further diagnostic investigation and imaging. We get referrals from GPs and specialists throughout Switzerland. Naturally, patients can also contact us directly to investigate any unexplained findings. We invite patients to an appointment in our outpatient clinic. We often need to take a tissue specimen (a biopsy) to confirm the diagnosis.
What is a biopsy?
A biopsy consists of taking a small piece of tissue from the tumor and examining it under the microscope. The biopsy tells us what type of tumor is present and how aggressively it is growing. At Balgrist University Hospital, we perform all biopsies as gently as possible, using minimally invasive techniques. A fine needle is inserted into the tumor under CT or ultrasound guidance. This procedure can be done as an outpatient and our anesthetists make sure that it is as comfortable as possible for the patients.
What operations are carried out on bone and soft-tissue tumors?
The top priority is to remove the tumor completely. Thanks to huge surgical advances, only exceptional cases now need an amputation. Our aim is to restore the function of the affected arm or leg as much as possible. Tumor surgery is a team effort by cancer and joint specialists, so that our patients benefit from all the know-how available in the orthopedic hospital.
Planning the tumor resection
Balgrist is the only hospital in Switzerland where specialists can establish a 3D model of the tumor and use the computer to plan its removal to the millimeter. During the operation, specially made templates from the 3D printer are used to convert the planning precisely into surgical reality. Before the operation, we have a personal discussion with the patient to explain the various steps in the surgical procedure and answer any questions they may have.
How can you replace the bone that has been removed?
After the complete resection of a tumor, a defect is often left in the bone. To preserve the function of the limb as much as possible, team leaders and the senior consultants look at the possibility of joint replacement: if the cancer also involves the joint it is possible to use a special prothesis. Balgrist University Hospital has internationally renowned expertise in replacement joints. If the cancer does not affect the joint, we can use bone from a donor (an allograft).
How can you replace soft tissues?
In rare cases, the cancer grows around important soft-tissue structures such as blood vessels and nerves, which also have to be removed at the time of operation. Our senior consultant in hand and nerve surgery has many years’ in-depth experience in suturing blood vessels and nerves. Short sections of nerve can be replaced with a cutaneous nerve from the lower leg; arteries can be ‘bridged’ with a vein graft. In Dr. Dominik Kaiser, the tumor team has an expert in soft-tissue reconstruction. Such surgical procedures are necessary when the removal of a large tumor makes to impossible to close the skin with sutures. In this situation, the tissue is covered with a skin graft or a muscle flap. And there is always the possibility of cooperating with other surgical disciplines.
The diagnosis and treatment of a tumor is very stressful for patients and their relatives. Our specialists discuss matters thoroughly and take enough time to address any questions or fears that the patient may have. In addition to the medical aspects, patients often face considerable organisational challenges at the workplace or during the hospital stay. Nicole Züger of our social services department offers support with expert advice and great understanding. If need be, we can easily call on specialists from the Zurich Cancer League when the patient is suffering from mental stress (psycho-oncology).
The most important step in treatment is correct surgical removal of the tumor. Careful surgery usually suffices for benign tumors and basically no further treatment is needed. Patients with malignant tumors may require additional chemotherapy or radiotherapy after the surgery.
Once treatment has finished, patients with cancer are followed up regularly. Patients appreciate the follow-up provided in the tumor team outpatient clinic. It means that they are always seen by the same person and can build up a trusting relationship. There is no unpleasant waiting time, as the radiological examinations are followed directly by review and discussion in the clinic. Patients who have to travel long distances, for example from the cantons of Ticino or Graubünden, are also happy make the journey to Balgrist for follow-up.
Special outpatient clinics for rare diseases
Together with the Zurich University Hospital and the Children’s Hospital, Balgrist University Hospital cares for patients who have rare diseases of the musculoskeletal system. The internationally recognised terms for such conditions are ‘rare diseases’ or ‘orphan diseases’. Hereditary errors of connective tissue or bone (e.g. Ehlers-Danlos syndrome, Marfan’s syndrome or osteogenesis imperfecta) and metabolic disorders lead to considerable restriction of the patient’s everyday life. Although many different organs are involved in the disease, the effects on the musculoskeletal system give rise to particularly bothersome complaints.
Various specialists (cardiology, rheumatology, endocrinology, orthopedics) work closely together in the field of rare diseases of the skeletal system and connective tissue. Dr Bianca Link, Senior Consultant at the University Children's Hospital, works with the orthopedic specialists at Balgrist University Hospital on two days a month. Dr. Daniel Müller and KD Dr. Böni of Balgrist University Hospital advise affected patients about the possibilism of conservative treatment (e.g. shoe modifications, splints or braces) and surgical options concerning the musculoskeletal system.
PD Dr. med. Daniel Andreas Müller
Dr. med. Dominik Kaiser
Interdisciplinary tumor surgery specialists
Prof. Dr. med. Mazda Farshad, MPH
Prof. Dr. med. Andreas Schweizer
PD Dr. med. Patrick Zingg
PD Dr. med. Sandro Fucentese
PD Dr. med. Karl Wieser
KD Dr. med. Thomas Böni
KD Dr. med. Stephan Wirth
Interdisciplinary outpatient clinic at the Sarcoma Center Zurich
The treatment of sarcomas requires close cooperation between various specialists. Every week specialists from Balgrist University Hospital, the Zurich University Hospital, and the Zurich University Children’s Hospital hold a sarcoma board meeting to plan optimal treatment. Balgrist University Hospital heads the sarcoma board together with the Department of Oncology at Zurich University Hospital, and is responsible for musculoskeletal tumors.
So that patients can benefit directly from the close cooperation between the different specialties, we hold interdisciplinary outpatient clinics. During consultations, the specialists discuss the therapeutic options with the patient: surgery, radiotherapy, and medication.
Please contact us if you would like more information.
An extensive infrastructure and optimal resources at Balgrist Campus are available for the Sarcoma Center to carry out research on musculoskeletal sarcomas.
- Swiss Center for Muskuloskeletal Biobanking (SCMB)
The SCMB is a national reference center for the collection, storage, and analysis of blood samples and tissue specimens.
- Unit for Clinical and Applied Resarch (UCAR)
UCAR identifies diagnostic and treatment methods that are still unsatisfactory today. Working closely with research institutes, they develop solutions for improvement.
New cancer cells are isolated from the blood of affected patients, in order to quantify the response to treatment rapidly and more accurately.
National and international networking
As bone and soft-tissue tumors are rare diseases, continual information exchange with other cancer specialists is extremely important. The Tumor Team at Balgrist University Hospital has close links with other hospitals at home and abroad. On the initiative of Balgrist University Hospital, university orthopedic departments throughout Switzerland have agreed to cooperate in the treatment of bone and soft-tissue tumors.
In addition, the Balgrist Tumor Team works closely with the internationally renowned university hospitals in Pisa (Prof. Capanna), Florence (adult patients: Prof. Campanacci; children: Dr. Beltrami), Paris (Prof. Masquelet) and the Memorial Sloan Kettering Cancer Center in New York (Prof. Healey).
Sarcoma research team
PD Dr. med. Daniel Andreas Müller
Downloads (available only in German)
Information for referring doctors
We specialize in the investigation and treatment of benign and malignant tumors of the musculoskeletal system. When a possible tumor of the bone or soft tissues is suspected, we are responsible for the appropriate work-up with diagnostic imaging and (CT- or ultrasound-guided) minimally invasive biopsies.
We offer the entire spectrum of state-of-the-art orthopedic tumor surgery. In addition to the resection of benign and malignant tumors, we perform complex reconstructions of bones and joints. The German Cancer Society audits our treatment results each year and we are successfully accredited as a musculoskeletal tumor center. Balgrist University Hospital has the highly specialized medicine (HSM) service contract for the treatment of primary malignant sarcoma in the Canton of Zurich. Together with the Cancer Center in Zurich, we are responsible for managing the Sarcoma Center. The Sarcoma Board works out a personalized treatment plan for each patient to ensure optimal cooperation between surgery, oncology, and radio-oncology.
Indications and range of services
The tumor team led by Dr. Daniel Müller specializes in the following
- Resection of benign soft-tissue tumors
- Treatment of malignant soft-tissue tumors (soft-tissue sarcomas) as part of the Sarcoma Center
- Reconstructive soft-tissue surgery, working together with plastic and vascular surgeons
- Resection/curettage of benign changes in the bone
- Treatment of malignant bone tumors (bone sarcomas) as part of the Sarcoma Center
- Reconstruction of joints and large bone defects following tumor resection or due to bone metastases
We offer the following medical services
- Biopsy of undiagnosed changes in bones and soft tissues
- Minimally invasive techniques such as CT-guided radiofrequency ablation (RFA)
- Surgical treatment of all musculoskeletal tumors including metastases
- Cutting-edge technology for planning tumor resections with the aid of 3D computer models and patient-specific templates
- Reconstruction of large bone defects
- Interdisciplinary appointments for tumor patients together with our colleagues from the Zurich University Hospital departments of oncology and radio-oncology
- Lead at the Sarcoma Center, together with the Zurich Cancer Center
- Lead at the weekly Sarcoma Board sessions held for interdisciplinary treatment planning
- Comprehensive medical care of the patient during investigation and treatment
- Regular tumor follow-up
The benefit to your patients
Our medical services offer your patients the following advantages
- Rapid accurate investigation of undiagnosed findings in bones and soft tissues, with consultation, imaging and biopsy usually carried out on the same day
- An interdisciplinary appointment together with our colleagues from the Zurich University Hospital departments of oncology and radio-oncology, so that the various treatment options can be discussed directly with the patient
- Complete medical care from work-up and diagnosis through treatment to aftercare with regular follow-up visits
- All the expertise of a university hospital works to the patient’s advantage in the reconstruction of bones and joints
- We are the only hospital in Switzerland that creates 3D models and patient-specific templates for tumor surgery
- International networks and exchange of information with renowned tumor centers in Italy (Florence, Pisa) and the USA (New York, Boston)
- Basic scientific research on the isolation and analysis of free circulation tumor cells (CTCs) in the blood, also known as a liquid biopsy