Laboratory of muscle plasticity
Our teaching activities include the biological basis of muscle plasticity and its functional importance in the maintenance of the postural and locomotor system both in health and in disease states.
It includes university presentations and research-related training for Master’s and PhD students, as well as specialty trainees, on biomedical research projects concerning muscle plasticity in orthopaedics.
Our research team is addressing the mechanisms of clinical plasticity in skeletal muscles.
With animal studies and case-orientated clinical studies we are looking at different approaches to unresolved questions on the maintenance and re-establishment of muscle function in the context of an orthopaedic procedure. Our current projects include:
- Molecular and cellular characterisation of muscle changes with time after tendon rupture and repair
- Studies on the effects of genomic factors on muscle plasticity during rehabilitation interventions
- Pharmacological interventions to prevent atrophy of skeletal muscles and the associated increase in intramuscular fat content after a tendon rupture
To answer the biological questions, we are using the latest molecular biological technology, as well as classic microanatomical and biochemical methods on surgical biopsy specimens. We are focussing on the role of adhesive processes of muscle fibres in the regulation of the mechanical properties of the stress-modulated phenotype of skeletal muscle.