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Research projects

Clinical studies

Neural Stem Cell Trial

In addition to assessing safety, the trial did measure defined clinical endpoints, such as changes in sensation, motor, and bowel/bladder function. All patients received HuCNS-SC cells through direct transplantation into the spinal cord, and were temporarily immunosuppressed.

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STIMO

Electrical epidural stimulations (EES) of the spinal cord are clinically tested in order to improve standing and walking ability. The study is currently being carried out in collaboration between Lausanne University Hospital and the Spinal Cord Injury Centre at Balgrist University Hospital.

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Nogo Antibody Study

Nogo is a protein that is found only in the central nervous system, where it prevents nerve regeneration. Conversely, antibodies to Nogo encourage damaged nerves to grow again.

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EMSCI

The aim of this study is to provide the required clinical basis for the implementation of novel interventional therapies.

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Deep Brain Stimulation

The idea of this study is to make use of few remaining intact fibres of the spinal cord by electrical stimulation of a certain region in the brain in order to activate the local control centers of the spinal cord by a multiple amplified signal.

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Neuro rehabilitation

Upper extremities

Activity monitoring of the upper extremities during rehabilitation after spinal cord injuries (SCI).

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Lower Limbs

A mobile system for interactive unsupervised lower limb rehabilitation training with virtual reality, based on a further development of the existing stationary

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Movement Laboratory

New findings of the basic pathophysiological mechanisms underlying walking impairments in neurological disorders, thus, improving diagnosis, treatment, stratification and outcome prediction of patients.

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Inclusive Protocols

The aim of this project ist the development of accurate inclusion/exclusion criteria for SCI trial participants, whether they be complete (ASIA Impairment Scale A or AIS-A) or incomplete, (AIS-B to AIS-D).

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Neuro imaging

Relationship between changes in spinal cord and brain morphometry to clinical recovery following acute spinal cord injury.

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Neurourology

Sacral neuromodulation 

Sacral neuromodulation for neurogenic lower urinary tract dysfunction: A randomized, placebo- controlled, double blind clinical trial.

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The bladder and the brain - fMRI study

Supraspinal control of lower urinary tract function in patients with neurogenic and non-neurogenic bladder dysfunction.

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LUT and EEG

Evaluation of new approaches in the treatment and neurophysiological assessment of healthy and impaired human lower urinary tract function.

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Neurophysiology

Motor plasticity and training: cortical and spinal mechanisms

 

Human beings have an extremely highly developed cortico-motoneuronal system. This partly explains why their ability for functional regeneration in the case of complete spinal cord injury is comparatively poor.

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Motor cortical control of cooperative and non-cooperative hand movements

The main aim of this project is to compare the neuronal regulation of one-handed movements with the neuronal regulation of cooperative and non-cooperative bimanual movements.

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The role of proprioception in movement imagery, awareness and production

This study should provide new findings on how sensory information influences movement. For this purpose, we are comparing the motor areas of healthy people with those of patients with spinal cord injuries.

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Sensory evaluation

Supra- and spinal pain control

Changes within the sensory system following spinal cord injury (SCI) not only affect the individual specific sensory modalities (proprio-, noci-, mechano-, enteroception) but also physiological sensori-sensory interactions across the spinal and supra-spinal system.

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CHEPs in lower limbs and small fibre neuropathy

Small fiber integrity can be assessed with CHEPs but recording potentials from the lower extremities has been considered rather difficult and poorly reproducible. Therefore, we aimed to investigate the feasibility of CHEPs from lower extremities deploying our increased baseline stimulation protocol.

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Cold-evoked potentials

Cold allodynia, a symptom frequently encountered in individuals with SCI suffering from neuropathic pain, has so far escaped proper appreciation, owing to the absence of an objective method in order to functionally dissect the underlying spinal pathways. Thus, a new assessment paradigm to record cold-evoked potentials has been piloted.

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KFSP Neuro rehabilitation

Neuro-Rehabilitation: Strategies for Customized Treatments

Neuro-Rehabilitation is an essential component of neurological care. In many clinical disorders (traumatic and non-traumatic) the acute care (emergency management and diagnostics) and the subsequent therapy is complimented by rehabilitation treatment to fully exploit the potential of recovery, to assure that medical outcomes are sustainable and that they eventually become significant for the patient’s daily life.

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